Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mammary Gland and Breast Cancer Studies at Scale
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:50 pm
"Studies of Early Disease and Beyond"
8:50 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Types and Cell States in Normal Mammary Gland Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Predicting Mammary Tumor Initiation, Progression and Response by (Intravital) Imaging"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Mechanisms of Oriented Cell Division and Fate Decision in the Mammary Epithelium"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Cholesterol Biosynthesis ‘Bridges the KAP1’ to Mammary Gland Development at Pregnancy"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"AP-1 and YAP/TAZ Cooperatively Promote Multipotency Reactivation in Basal-Like Breast Cancer Tumorigenesis"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Rank Signaling Determines Mammary Cell Identity and Basal Luminal Crosstalk"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lessons From Human Genomic Studies
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:35 pm
"Single Cell and Spatial Profiling of the Breast Cancer Disease Trajectory"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Luminal Breast Epithelial Cells from Wildtype and BRCA Mutation Carriers Harbor Copy Number Alterations Commonly Associated with Breast Cancer"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Volumetric Analysis of the Terminal Ductal Lobular Unit Architecture and Cell Phenotypes in the Human Breast"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:45 pm
"Genomic Trajectories of Pre-Malignant and Invasive Breast Cancers and Clinical Implications"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Normal Mammary Gland Development in Mouse, Human and Other Mammals
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Elucidation of the Mammary Epithelial Hierarchy to Identify ‘Cells of Origin’ of Cancer"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Revisiting the Role of WNT Signaling in Breast (Cancer) Biology"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Comparative Analysis and Induced Tumorigenesis of Normal Human Mammary Cells from Male and Female Donors"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"A Fate Beyond Fat: Adipocyte Progenitors in the Mammary Stroma during Epithelial Expansion and Obesity"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Using Non-Traditional Model Species to Investigate Mammary Postnatal Development"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Tools and Technologies in Mammary Gland and Breast Cancer
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:35 pm
"Breast Cancer Dormancy: A Link to the Past?"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Establishing Conditions for the Generation and Maintenance of Estrogen Receptor-Positive Organoid Models of Breast Cancer"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Immune Modulation in Hippo Pathway Regulated Breast Tumour Microenvironments"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:45 pm
"Decoding Aneuploidy: Unveiling the Driver Genes of Basal-Like Breast Cancer Using In Vivo CRISPR Screening"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lactation Biology: New Insights into Epithelial and Immune Cells
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"From Voxels to Cells: Leveraging Light-Based Bioprinting for Mammary Tissue Engineering"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Plasticity of the Mammary Gland and its Implications for Lactation"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"The Milky Way, A Breast Organoid Journey"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Senescence is Important for Mammary Gland Involution and Postpartum Breast Cancer"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Identifying Factors That Regulate Epithelial Cell Functions during Lactation Using Single-Cell Multiomic Analysis"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Multiomic Analysis of The Breast in Health and Disease
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:35 pm
"Lobular Breast Cancer: Development and Progression"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
"Ductal Carcinoma In Situ : A Basal-Like to Luminal Transition"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Determining the Molecular Underpinnings of Treatment Response in TNBC Patients"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:45 pm
"The Role of the Microenvironment in BRCA1-Driven Breast Cancer Initiation"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Normal Development, Targeted Prevention and Treatment
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Novel Cancer Prevention Strategies for Women Carrying Pathogenic Variants in the BRCA1 or BRCA2 Gene"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Breast Cancer Etiologies across the African Diaspora"
10:20 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"Utilizing Hormonal Stimulation to Increase Proliferation of BRCA1-Mutant Premalignant Cells for PARPi Prophylactic Intervention"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"FABP7 Progenitors are a Targetable Metabolic Root in the BRCA1 Breast"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Targeting Progesterone Signalling Reduces Hallmarks of Breast Cancer Risk Through Epithalial-Stromal Remodelling"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Lessons From Embryonic and Adult Mammary Gland Development
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
"Back to the Future: Links Between Tissue Repair, Reprogramming to an Ambryonic-Like State, and Cancer"
6:45 pm - 7:00 pm
Discussion
7:00 pm - 7:40 pm
"Breast Cancer Metastasis: Act Locally, Think Globally"
7:40 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure